Since 2013, Amyot has been serving as the President and CEO of Colleges and Institutes Canada, the voice of Canada’s colleges, institutes, CEGEPS and polytechnics, and an international leader in education for employment in over 25 countries.

Previously, Amyot was the President and CEO of Federal Crown Corporation. She has worked as Assistant Deputy Minister at the federal level in her last three roles. She has worked in policy and programs in social, scientific, economic, and cultural areas both in Ottawa and in regions in several federal departments, including Human Resources Development Canada, National Defense, Natural Resources Canada, Indigenous and Northern Affairs, Canadian Heritage, the Public Service Commission, and the Canada Public Service Agency. She also worked as an administrator for the Department of Education of the Northwest Territories (NWT) and taught in Ontario, Quebec, and the NWT.

Amyot is a former Chair of the World Federation of Colleges and Polytechnics and current Chair of the Advisory Committee of the Institute of Science, Society and Policy (ISSP) and was appointed by the Government of Ontario to the Ontario Trillium Foundation Board for six years. Denise is a board member of the Forum for International Trade Training (FITT), the Canadian Centre for Science and Policy, Montfort hospital, and has been appointed by the Government of Canada on the Future of Skills Council of Canada.